Our Most Recent Patents Reveal Potential Stroke Prevention Methods and Formulations
Our two most recently published patents (link https://neohacksciences.com/newest-patents.) cover both methods and formulations with over 20 claims.
Stroke is associated with these disorders listed in the patents: type 2 diabetes, acute inflammation, blood pressure deviation, viral infections, and bacterial infections. Each condition contributes to stroke risk through distinct physiological mechanisms that impact the cardiovascular system. (link https://pmc.ncbi.nlm.nih.gov/articles/PMC11786524/)
The methods covered in the May 2025 patent includes easy to administer methods such as lozenges.
The formulations covered in the July 2025 patent use FEMA GRAS approved ingredients (https://www.femaflavor.org/gras) for safety. Key components cited include the following:
1. Beta Caryophyllene
2. Dexpanthenol
3. Spilanthol
4. Pellitorine
In the article referenced below, we have focused on the ability of our herbal based components to inhibit ICAM-1 and VCAM-1 which reduce the oxidative damage in the aftermath of loss of blood.
Certain cytokines are cited that our herbal components limit TNFa, INOS, IL-1, NLRP3, PI3K/AKT, p38MAPK, MMP's and VEGF-1 et al, all causing extensive oxidative damage.
(The review article in Frontiers in Cellular Science by Fu, X. et al, 2025, DOI 10.3389/fricel.2025.1536028)
Each of the following five disorders are cited in the patents in claims 9 and 12:
1. Diabetes type 2
Type 2 diabetes significantly increases the risk of stroke, with studies showing that people with diabetes have more than double the risk compared to non-diabetics.
- Accelerates atherosclerosis: High blood sugar levels can damage blood vessels over time, leading to fatty deposits and the narrowing of arteries. This is the primary mechanism for the increased risk of ischemic stroke.
- Worsens outcomes: In diabetic patients, both acute hyperglycemia during a stroke and chronic poor glycemic control are linked to worse clinical outcomes and higher mortality.
2. Acute inflammation
Acute inflammation is both a risk factor for and a consequence of ischemic stroke.
- Triggers stroke: A strong inflammatory response can trigger a stroke by causing plaque rupture, which leads to a clot. It can also create a prothrombotic, or clot-forming, state.
- Exacerbates brain damage: Following a stroke, the brain's inflammatory response can worsen tissue damage, increase blood-brain barrier permeability, and lead to brain edema.
3. Blood pressure deviation
High blood pressure is the most important and common
modifiable risk factor for stroke.
- Sustained high pressure: Chronic, uncontrolled high blood pressure puts constant strain on artery walls, which can weaken them and lead to a hemorrhagic stroke (a bleed) or make them more susceptible to blockages causing an ischemic stroke.
- High variability: Significant day-to-day or visit-to-visit fluctuations in blood pressure, known as blood pressure variability (BPV), are also independently associated with a higher risk of stroke.
4. Viral infections
Viral infections, whether acute or chronic, can increase stroke
risk through several mechanisms.
- Acute infection: Severe infections like influenza and COVID-19 are linked to a temporary, elevated risk of stroke. They can trigger inflammation and increase the risk of blood clots.
- Chronic infection: Persistent infections, such as those caused by herpesviruses (e.g., varicella-zoster virus) and HIV, have been associated with cerebral vasculopathy, where the viruses invade and damage the blood vessel walls.
5. Bacterial infections
Bacterial infections are also associated with an increased risk of
stroke, especially in the short-term following an acute infection.
Inquiries:
We invite inquiries for further information about acquiring licensing to use our patented methods and formulation via this link https://neohacksciences.com/contact-and-license
